Assessment of template-based protein structure predictions in CASP10
نویسندگان
چکیده
منابع مشابه
Assessment of CASP10 contact-assisted predictions.
In CASP10, for the first time, contact-assisted structure predictions have been assessed. Sets of pairs of contacting residues from target structures were provided to predictors for a second round of prediction after the initial round in which they were given only sequences. The objective of the experiment was to measure model quality improvement resulting from the added contact information and...
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In CASP7, protein structure prediction targets that lacked substantial similarity to a protein in the PDB at the time of assessment were considered to be free modeling targets (FM). We assessed predictions for 14 FM targets as well as four other targets that were deemed to be on the borderline between FM targets and template based modeling targets (TBM/FM). GDT_TS was used as one measure of mod...
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We develop and test a new pipeline in CASP10 to predict protein structures based on an interplay of I-TASSER and QUARK for both free-modeling (FM) and template-based modeling (TBM) targets. The most noteworthy observation is that sorting through the threading template pool using the QUARK-based ab initio models as probes allows the detection of distant-homology templates which might be ignored ...
متن کاملA Contact-Assisted Approach to Protein Structure Structure Prediction and Its Assessment in CASP10
Among different approaches to predict the 3D structure of a protein, one important idea is to predict a protein residueresidue contact map and then construct a full 3D structure from the contact-map. Instead of building a structure purely from contacts information, here we describe a contactassisted structure prediction approach that uses only a few known contacts to improve the quality of alre...
متن کاملA Contact-assisted Approach to Protein Structure Prediction and Its Assessment in CASP10
Among different approaches to predict the 3D structure of a protein, one important idea is to predict a protein residueresidue contact map and then construct a full 3D structure from the contact-map. Instead of building a structure purely from contacts information, here we describe a contactassisted structure prediction approach that uses only a few known contacts to improve the quality of alre...
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ژورنال
عنوان ژورنال: Proteins: Structure, Function, and Bioinformatics
سال: 2014
ISSN: 0887-3585
DOI: 10.1002/prot.24488